What Does this Failure to Develop Resistance Say About Unaided Macro-Evolution?

So it turns out that this tuberculosis bacteria has been trying for seven decades to develop resistance to a particular anti-biotic that will still permit it to be viable- without success. This is equal to many millions of generations of bacteria in a population of many billions which were under stress due to the anti-biotic.

Does this say anything about the limits of purely natural evolution? I think so. Even if other bacteria species have made the jump and developed resistance to an anti-biotic (at the cost of reduced fitness otherwise) this one seems to have hit on a hard biological limit which unguided evolution cannot move it past. Surely this is not the only such hard limit in earth's living things. If this organism can't make this jump, how likely is it that the same mechanisms can cause a deer-like animal to develop into various types of whales in probably much fewer generations and far less tries?

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